Option 1: Integrate with your laboratory information system (LIS)
Integrate clonoSEQ into your institution’s laboratory information system where ordering is as simple as logging in and completing the order form. Contact us for assistance with this process at 855-466-8667.
Option 2: Set up an individual account
Complete the account registration form on the Order page. Each physician who will place an order needs to submit a form. Once the form has been approved, you'll just need to fill out the short order form for each patient sample sent. Securely fax your order to Adaptive at: 866-224-1645
The clonoSEQ assay focuses on the T cell receptor or B cell receptor (Ig) Complementarity Determining Region 3 (CDR3) area. The nucleotide sequences that encode the CDR3 regions are generated by site-specific recombination between genomic variable (V), diversity (D), and joining (J) region gene segments (Figure A).
Because of the inherent diversity of receptors that are formed, it is highly improbable that the same CDR3 nucleotide sequence will be independently created twice, effectively making each CDR3 sequence a unique nucleotide tag for any specific T cell or B cell and its clonal descendants (Figure B ).
This unique nucleotide tag (Figure C ) is the marker utilized to track the malignant T or B cell over time via a proprietary multiplex PCR technology paired with next-generation sequencing and refined computational analysis.