Understanding Your Report

Let’s take a closer look at your child’s reports

Your child’s doctor will likely order the clonoSEQ test multiple times in order to track your child’s progress. These test results will be delivered to your child’s doctor in the form of a report. Below are two types of reports you may see after your child is tested with clonoSEQ.

Be sure to talk to your child’s doctor about the optimal timing for MRD testing with clonoSEQ

The Clonality (ID) Test is a one-time baseline summary that identifies the dominant DNA sequences related specifically to your child’s individual cancer. If a dominant sequence (or multiple sequences) is identified, it will act like a barcode in all of your child’s subsequent Tracking (MRD) Tests, helping their doctor assess your MRD throughout treatment.

Sample Clonality (ID) Report

Tap numbers on the report for more information.

Clonality ID report

Clonality (ID) Status

The number of trackable DNA sequences that were identified. Your child may have one DNA sequence or multiple DNA sequences.

In rare cases, a dominant sequence may not be identified. If this occurs, we will work with your child’s doctor to identify other specimen options.

Talk to your child’s doctor about ordering their Clonality (ID) Test upfront, so you can have a baseline for their future MRD tests. Ask your child’s doctor how often they will be testing with clonoSEQ and receiving your child’s reports.

These reports are called the Tracking (MRD) Reports. These reports provide an ever-evolving picture of your child’s cancer, so you and their doctor can make more informed treatment decisions.

Sample Tracking (MRD) Report

Tap numbers on the report for more information.

MRD Report

Your Child’s MRD Status

A positive (+) result means residual disease was detected. A result of zero means residual disease was not detected. Each report will provide your child’s updated MRD status.* You can gain valuable insights about your child’s cancer regardless of your child’s result.

Talk with your child’s doctor about their MRD status to better understand what your child’s result means for them and their treatment plan.

*False-positive or false-negative results may occur for reasons including, but not limited to: contamination, technical, and/or biological factors.

MRD Level

This number shows the amount of cancer present in your child’s sample. Your child’s doctor can help put this number into context based on the current phase of their care and treatment goals.

MRD Trends

A graph will show any changes detected in your child’s MRD level over time. Watching these changes may help you and your child’s doctor better understand their response to treatment and track any changes in their cancer levels.

Here are some questions to help you start a conversation with your child’s doctor.

  • How will you incorporate MRD results from clonoSEQ into my child’s treatment plan?
  • How often should my child get a clonoSEQ test?
  • What does a positive or negative MRD status with clonoSEQ mean?
  • Is the goal of MRD negativity with clonoSEQ right for my child?

This page is intended for a US-based audience.

clonoSEQ® is available as an FDA-cleared in vitro diagnostic (IVD) test service provided by Adaptive Biotechnologies to detect measurable residual disease (MRD) in bone marrow from patients with multiple myeloma or B-cell acute lymphoblastic leukemia (B-ALL) and blood or bone marrow from patients with chronic lymphocytic leukemia (CLL). Additionally, clonoSEQ is available for use in other lymphoid cancers and specimen types as a CLIA-validated laboratory-developed test (LDT). To review the FDA-cleared uses of clonoSEQ, visit clonoSEQ.com/technical-summary.