About MRD

Keeping an eye on your cancer is an essential part of treating it

clonoSEQ is a test that helps your doctor keep an eye on your MRD throughout your cancer journey

  • Understand your cancer and make a treatment plan1
  • Assess how the amount of cancer in your body is changing over time2
  • Uncover information other tests
    may miss2,3,6-8
  • Measure your response to treatment, and potentially adjust your treatment plan to improve the outcome4
  • Detect the return of cancer before physical signs and symptoms arise2,9-14

The insights you and your doctor get from clonoSEQ MRD testing can support shared decision-making throughout the course of your care

In a survey of multiple myeloma patients who reported having MRD testing15:


found it useful


said it gave them more confidence


said it helped them make treatment decisions

Here are some questions to help you start a conversation with your doctor.

  • What is MRD?
  • How will measuring MRD inform decisions related to my cancer treatment?
  • At what points during my treatment plan might I need MRD testing?
  • What might a positive or negative MRD result mean for me?


  1. clonoSEQ®. [technical summary]. Seattle, WA. Adaptive Biotechnologies; 2020.
  2. Pulsipher M, et al. Blood. 2015;125(22):3501-3508.
  3. Wood B, et al. Blood. 2018;131(12):1350-1359.
  4. Perrot A, et al. Blood. 2018;132(23):2456-2464.
  5. Thompson P, et al. Blood. 2019;134(22):1951-1959.
  6. Short N, et al. Blood Adv. 2022;6(13):4006-4014.
  7. Pulsipher M, et al. Blood Cancer Discov. 2022;3(1):66-81.
  8. Avet-Loiseau H, et al. Blood. 2015;126(23):191.
  1. Logan A, et al. Biol Blood Marrow Transplant. 2014;20(9):1307-1313.
  2. Roschewski M, et al. Lancet Oncol. 2015;16(5):541-549.
  3. Rezazadeh A, et al. Clin Lymphoma Myeloma Leuk. 2023;2152-2650.
  4. Al-Sawaf O, et al. J Clin Oncol. 2021;39(36):4049-4060.
  5. Martinez-Lopez J, et al. J Hematol Oncol. 2021;14(1):126.
  6. Costa L, et al. Lancet Haematol. 2023;10(11):e890-e901.
  7. Hydren J, et al. Paper presented at: 65th ASH Annual Meeting and Exposition; December 9-12, 2023; San Diego, CA. Abstract 2410.