Understanding Your Report
Let’s take a closer look at the clonoSEQ reports
Your doctor will likely order clonoSEQ MRD testing at several points throughout your treatment journey to assess your response to therapy and inform the clinical decisions you make together. Your MRD test results will be delivered to your doctor in the form of a clonoSEQ report. There are two types of clonoSEQ reports you may review with your doctor.
Be sure to talk with your doctor about the optimal timing for MRD testing with clonoSEQ
Your first test
Your doctor will likely order your first clonoSEQ test early in your journey—ideally, sometime after your initial diagnosis.
The Clonality (ID) Test is a one-time baseline summary that identifies the dominant DNA sequences related specifically to your individual cancer. If a dominant sequence (or multiple sequences) is identified, it will act like a barcode in all of your subsequent Tracking (MRD) Tests, helping your doctor assess your MRD throughout treatment.
Sample Clonality (ID) Report
Tap numbers on the report for more information.
Clonality (ID) Status
The number of trackable DNA sequences that were identified. You may have one DNA sequence or multiple DNA sequences.
In rare cases, a dominant sequence may not be identified. If this occurs, we will work with your doctor to identify other specimen options.
Talk to your doctor about ordering your Clonality (ID) Test upfront, so you can have a baseline for your future MRD tests. Ask your doctor how often you will be testing with clonoSEQ and receiving your reports.
Your Tracking (MRD) Tests
Once your dominant cancer DNA sequence(s) are identified, you will be tested periodically so your doctor can monitor your cancer.
These reports are called the Tracking (MRD) Reports. These reports provide an ever-evolving picture of your cancer, so you and your doctor can make more informed treatment decisions.
Sample Tracking (MRD) Report
Tap numbers on the report for more information.
Your MRD Status
A positive (+) result means residual disease was detected. A result of zero means residual disease was not detected.* The number next to the positive result tells you how much circulating tumor DNA was detected in your blood specimen.
Talk with your doctor about your MRD status to better understand what your result means for you and your treatment plan.
*False-positive or false-negative results may occur for reasons including, but not limited to: contamination, technical, and/or biological factors.
Total MRD Level
This is the total DNA sequences or amount of cancer detected in your sample. The number of copies detected in the box is a reflection of that particular sample, not the tumor multiplying.
Sample Level Results Over Time
This graph will show any changes in your MRD level over time. These are “sample level” results, meaning that the cancer DNA sequence that was seen the most in your sample is the one plotted on the graph.
Watching these changes may help you and your doctor better understand your response to treatment and track changes in your cancer cells over time.
Talk to your doctor about clonoSEQ
Here are some questions to help you start a conversation with your doctor.
- How will you incorporate MRD results from clonoSEQ into my treatment plan?
- How often should I get a clonoSEQ test?
- What does a positive or negative MRD status with clonoSEQ mean for me?
- Is the goal of MRD negativity with clonoSEQ right for me?
Looking for more resources?
This page is intended for a US-based audience.
clonoSEQ® is available as an FDA-cleared in vitro diagnostic (IVD) test service provided by Adaptive Biotechnologies to detect measurable residual disease (MRD) in bone marrow from patients with multiple myeloma or B-cell acute lymphoblastic leukemia (B-ALL) and blood or bone marrow from patients with chronic lymphocytic leukemia (CLL). Additionally, clonoSEQ is available for use in other lymphoid cancers and specimen types as a CLIA-validated laboratory-developed test (LDT). To review the FDA-cleared uses of clonoSEQ, visit clonoSEQ.com/technical-summary.